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It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40

On-Treatment Analysis (If Everyone Stayed on Max Dose): CagriSema achieved 22.7% weight loss using trial-product estimand (assumes perfect adherence at max dose)

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