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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

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68 69 Stress management

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The Study Researchers applied intermittent theta-burst stimulation (iTBS)a rapid form of repetitive TMSto both cerebellar hemispheres for 21 consecutive days (126 sessions, ~75,600 pulses)