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Despite this being prominent in the news, the first medication mentioned by GPs and IMs when asked Which drugs for managing of patients living with obesity are you aware of, even if you have not prescribed them? was, in 54% of responses, the much older and less effective orlistat and its brand names Xenical and Alli (figure 1)
In India, Torrent is pursuing a similar first-mover strategy
The rationale for this approach was to investigate if GLP-1 signalling could cause metabolic reprograming that would persist after removal of receptor stimulation (Fig
2016;4 [cited 2018 Aug 13]
Glucagon-like peptide-1 receptor agonists (GLP1-RA) are emerging as novel anti-diabetic and weight-loss medications for the treatment of T2D and obesity 26
