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The combination of PL and the glutaminase inhibitor CB-839 has been shown to exhibit a synergistic effect, resulting in a significant reduction in cell viability and levels of lipid peroxidation (LPO)

Brain Behav Immun 115:312 Osimo EF, Pillinger T, Rodriguez IM et al (2020) Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls

doi: 10.3390/antiox10050651 6

Contraindications include known copper sensitivity, active malignancy, and pregnancy

This is especially important for those with genetic polymorphisms in glutathione genes

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