This dual action often produces more pronounced appetite suppression and potentially greater weight loss results compared to GLP-1-only medications
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BMJ Open Diabetes Res Care 8(2):e001649 Furusawa S, Nomoto H, Yokoyama H, Suzuki Y, Tsuzuki A, Takahashi K, Miya A, Kameda H, Cho KY, Takeuchi J, Nagai S, Taneda S, Kurihara Y, Nakamura A, Atsumi T (2023) Glycaemic control efficacy of switching from dipeptidyl peptidase-4 inhibitors to oral semaglutide in subjects with type 2 diabetes: a multicentre, prospective, randomized, open-label, parallel-group comparison study (SWITCH-SEMA 2 study)
Additionally, oleic acid reduces ceramide content and ROS production, which increase due to prolonged exposure to high levels of palmitate [140] (Fig