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A recent publication describes similar results with broad ActRIIA/B receptor blockade during GLP-1 RA-induced weight loss in obese mice, i.e., prevention of muscle loss with increased fat loss, resulting in multiple metabolic benefits 45

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One of the first questions many people ask is: Who are GLP-1 medications for

Side-effect tracking that gets it Log nausea, fatigue, constipation and more on a severity scale

For context, the dual agonist tirzepatide is studied in SURMOUNT ( NEJM , 2022) and SURMOUNT-OSA ( NEJM , 2024)

Efpeglenatide and clinical outcomes with and without concomitant sodium-glucose cotransporter-2 inhibition use in type 2 diabetes: exploratory analysis of the AMPLITUDE-O trial