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The complexity and heterogeneity of complex I disorders can be emphasized by the constellation of disorders termed MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes

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Yes, vitamin B12 works well with other treatments

The catch is that the effect requires consistent, high-dose exposure, fades when treatment stops, and works very unevenly between individuals

Dosing guidelines suggest starting at a dose of 1.5 milligrams and gradually increasing to the maintenance dose (the dose found to be most effective in clinical trials) of 25 mg, depending on how the person responds and how strong side effects are

This means that the FDA has not verified their safety, effectiveness, or quality