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Thus, the optimization of UA level can be regarded as a systemic issue

2.3.5 Metabolites 2.3.5.1 Blood glucose Chronic hyperglycemia enhances the proinflammatory response in lipopolysaccharide-stimulated macrophages, including the production of TNF-, IL-1, and IL-6 (160)

Oxidized glutathione (GSSG) has already donated its electrons and must be converted back to GSH by glutathione reductase before it can function as an antioxidant again

We flag it only to be complete and honest about where the science actually stands, because responsible information means clearly separating what is proven from what is still being studied

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