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Kainer et al
Although many E1 inhibitors have been developed, except for MLN4924, none has entered clinical trials, most likely due to issues of specificity or poor drug-like properties
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That could inform dosing and treatment for people with HIV and the broader population in the future
And the questions it opens about the neural architecture of desire, the melanocortin systems role in behavior, and the future of centrally-acting pharmacology remain among the most compelling in contemporary peptide science
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