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Dauriz M, Targher G, Temporelli PL, Lucci D, Gonzini L, Nicolosi GL, Marchioli R, Tognoni G, Latini R, Cosmi F, et al Prognostic impact of diabetes and prediabetes on survival outcomes in patients with chronic heart failure: a post-hoc analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial J Am Heart Assoc

Tirzepatide is a popular dual GIP/GLP-receptor agonist sold by Eli Lilly and Company under the brand names Zepbound and Mounjaro

This combination promotes the increase of GH by both increasing the strength of the GH release pulse and increasing the number of cells that secrete GH with the two pathways converging on the somatotroph to produce a supraphysiological GH response that neither compound achieves independently

Adverse reactions Skin reactions Skin reactions are the most common adverse reactions, mainly including the following: Excessive pigmentation: Melanotan peptide promotes melanin production, which may lead to excessive skin pigmentation, uneven pigmentation spots or freckles