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Treatment typically involves vitamin B12 supplementation, either through oral supplements or injections, depending on the severity of the deficiency and underlying causes.

Hormonal influences, reproductive demands, and autoimmune conditions affecting gastric absorption (e.g., pernicious anemia, thyroid disease) may predispose women to deficiency, while greater health-seeking behavior increases test frequency

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Pushing a patient past their tolerability threshold often leads to protocol abandonment